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Pre- and post-operative prophylactic agent in intraocular surgery to prevent endophthalmitis.
Moxifloxacin is fourth-generation fluoroquinolone, having broad-spectrum antibiotic activity & more effective than ciprofloxacin or levofloxacin in keratitis.
The bactericidal activity by the inhibition of DNA gyrase (topoisomerase II) and topoisomerase IV.
Effectively inhibits Staph aureus in early & late phase infection which is major pathogen in bacterial Keratitis.
Moxifloxacin shows broad spectrum antibiotic activity & act as potent bactericidal.
It shows greater antibacterial effects against gram-positive bacteria compared to second & third generation fluroquinolones.
Ketorolac Tromethamine shows complete inhibition of PG (Prostaglandine) synthesis in aqueous humor & relieves pain after Radial keratotomy, Photorefractive keratectomy & LASIK.
Better efficacy to reduce inflammation after cataract surgery.
- Bacterial Conjunctivitis
- Treatment of aphakic & pseudophakic macular edema.
- Reduces Inflammation after Cataract Surgery.
For Enhanced Action
Moxifloxacin has Superior corneal and aqueous penetration ability.
Moxifloxacin is the most potent & least resistant antibiotic due to addition of C-8 methoxy group which increases potency.
Contains Loteprednol,A novel C-20 ester-based corticosteroid.
Loteprednol is retro metabolically designed to offer potent anti-inflammatory efficacy.
Loteprednol has lower propensity to increase IOP relative to Prednisolone acetate or Dexamethasone.
Contains, Gatifloxacin 0.3% w/v which is act as broad spectrum antimicrobial activity
Useful in the treatment of ocular infections in endophthalmitis & conjunctivitis with the killing of stationary & active growth phase of E. coli & staphylococci.
Benzalkonium Chloride as a preservative that has been consistently demonstrated to have synergistic antibacterial activity in vitro.
Checkmate for Bacteria.
Contains Nepafenac 0.1% w/v which is act as a pro-drug with superior penetration of the cornea & scleral tissues.
Nepafenac has approved by USFDA for the treatment of pain and inflammation associated with cataract surgery.
Inhibits both COX-1 & COX-2 activity as well as preventing vision loss due to Diabetic Macular Edema.
NSAID designed for Eyes.
Difluprednate Ophthalmic Emulsion 0.05% w/v.
Difluprednate is USFDA Approved Corticosteroid for Pain & Inflammation & it has corneal penetration which is enhanced by substituting the 21-hydroxyl group with acetate.
Emulsion provides better ocular bioavailability & effective in treating both postoperative inflammation & anterior uveitis.
Penetrates the corneal epithelium rapidly & effectively as well as it reduces retinal thickness in patients with refractory Diabetic Macular Edema.
Rapid onset of anesthesia in 30 seconds with single drop.
Safe & effective as an analgesic.
Can use in the management of acute corneal injuries in the emergencies.
Ideal Topical Ocular Anesthetic.
Ideal Topical Ocular Anesthetic
- Conjunctivitis: Recommended in the treatment of Bacterial Conjunctivitis.
- Hordeolum: Greater Clinical & bactericidal activity in Hordeolum / Stye.
- Orbital Cellulitis: Greater Susceptibility against S. pneumonia, S. pyogenes, S.aureus & H. influenza in Orbital Cellulitis.
- Dacryocystitis: Greater Susceptibility against Staphylococci, Streptococci & Diphtheroids in the treatment of Dacryocystitis.
Most Prefered Combination
It is combination of Amino Glycoside & Corticosteroid which provides relief from infections & inflammations.
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis.
Tobramycin may also destabilize bacterial membrane&Corticosteroids are act by the inhibition of phospholipase A2 inhibitory proteins.
These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Provides excellent activity against clinically relevant Ocular Pathogens.
Moxifloxacin has better antibacterial activity against Gram positive but less than desirable activity against Gram Negative Bacteria & Tobramycin has better antibacterial activity against Gram Negative specially Pseudomonas species.
Contains combination of Moxifloxacin & Tobramycin so it is providing eradication against Gram Positive & Gram Negative bacteria.